{"id":1848,"date":"2021-03-02T12:50:10","date_gmt":"2021-03-02T12:50:10","guid":{"rendered":"https:\/\/necotox.de\/?p=1610"},"modified":"2023-07-10T17:52:03","modified_gmt":"2023-07-10T17:52:03","slug":"verknupfung-der-oecd-tg-318-mit-der-gd-318","status":"publish","type":"post","link":"https:\/\/necotox.de\/en\/verknupfung-der-oecd-tg-318-mit-der-gd-318\/","title":{"rendered":"Linking The OECD TG 318 with The GD 318"},"content":{"rendered":"<p>Previously we informed about the <a href=\"https:\/\/www.oecd.org\/chemicalsafety\/nanomet\/\">NANOMET<\/a> Workshop on the subject\u00a0<a href=\"https:\/\/necotox.de\/en\/special-requirements-for-the-ecotoxicological-assessment-of-nanomaterials-oecd-gd-no-317\/\">OECD Guidance (DG) 317 on aquatic and sediment toxicity testing of nanomaterials.<\/a>. At the end of last week, another NANOMET online seminar took place. There, the scope, content and practical application of the <a href=\"https:\/\/www.oecd-ilibrary.org\/environment\/test-no-318-dispersion-stability-of-nanomaterials-in-simulated-environmental-media_9789264284142-en\">Test Guideline (TG) 318<\/a> was discussed. It focused in particular on the determination of the dissolution rate, but also on the stability of the dispersion for toxicity tests, which were performed in the<a href=\"https:\/\/www.oecd.org\/officialdocuments\/publicdisplaydocumentpdf\/?cote=env\/jm\/mono(2020)9&amp;doclanguage=en\">\u00a0Guidance Document 318<\/a>.<\/p>\n<p><iframe src=\"https:\/\/www.youtube.com\/embed\/Ytg0IrbwNj4\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><del datetime=\"2021-03-09T11:25:01+00:00\">Currently, unlike the last presentation of DG 317, there is unfortunately no publicly available recording of the online seminar<\/del>. Update: In the meantime, the corresponding recording has been uploaded and is now publicly available on YouTube. We have embedded the YouTube video below.<\/p>\n<p><iframe src=\"https:\/\/www.youtube.com\/embed\/ODEQGkFonAo\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p>Da wir jedoch bereits <a href=\"https:\/\/necotox.de\/en\/nanoregulations-fate-of-engineered-nanomaterials-in-the-aquatic-environment\/\">informed about the OECD Guideline 318<\/a> in einem unserer fr\u00fcheren Beitr\u00e4ge \u2013 auch mit einem Link zu unserer entsprechenden Videopr\u00e4sentation (oben) \u2013 m\u00f6chten wir Sie heute \u00fcber den Umfang und den Inhalt des 53 Seiten starken Begleitdokuments GD 318 informieren.<\/p>\n<p>Scope of OECD DG 318<\/p>\n<p>The dissolution rate, but also the dispersion stability of nanomaterials in the environment are very important parameters. These ultimately affect their fate and thus have a direct impact on the assessment of their environmental risks. Since dissolution rate and dispersion stability are often interdependent, an overarching guidance document linking these factors was needed. This is now presented by OECD DG 318.<\/p>\n<p>The document deals with methods for evaluating the dissolution rate and dispersion stability of nanomaterials in aqueous environmental media. It is relevant for nanosolids, but also for their aggregates and agglomerates. Specifically, the GD provides guidance on the influence of different experimental conditions on the performance and results of the methods used. In addition, modifications and\/or additions to these methods are discussed in the document.<\/p>\n<p><strong>OECD DG 318 content [reference to the relevant chapters].<\/strong><\/p>\n<p>1. flow-through and test-bench methods for determining solubility and dissolution rate [Chapter 2].<\/p>\n<p>2. specific guidance on TG 318 [Chapter 3]:<\/p>\n<ul>\n<li>Additional experimental conditions<\/li>\n<li>Support for consideration of heteroagglomeration.<\/li>\n<li>Derivation of fastening coefficients<\/li>\n<li>Guidelines for the interpretation and presentation of data related to the endpoint.<\/li>\n<\/ul>\n<p>3. the use of the obtained data for further fate and effect tests \/ evaluation strategies and the influence of two endpoints on each other, e.g. dispersion stability on dissolution rate and vice versa, is discussed [Chapter 4].<\/p>\n<p>4. recommendations for the use of baseline data to derive input data \/ parameters for exposure modeling [Chapter 5].<\/p>\n<p>5. use of the DG with respect to other [future] OECD TGs and DGs [Chapter 6].<\/p>\n<ul>\n<li>Aquatic and sediment toxicity testing<\/li>\n<li>Accumulation potential of nanomaterials in fish<\/li>\n<li>Estimation of fate in soil and sediment: advice on screening options for dispersion stability and dissolution rates under different environmental conditions.<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.oecd-ilibrary.org\/environment\/test-no-318-dispersion-stability-of-nanomaterials-in-simulated-environmental-media_9789264284142-en\">Here is a link to the document on the OECD website.<\/a>.<\/p>\n<p>Contact us if you have any questions, need a consultation, or if you would like us to conduct the study for you.<br \/>\nWe have experience and have the appropriate equipment ready for you.<br \/>\nAlso feel free to like or share the video above if you would like to see more nEcoTox content on <a href=\"https:\/\/www.youtube.com\/watch?v=Ytg0IrbwNj4&amp;feature=youtu.be\">Youtube<\/a>.<\/p>\n<p>Mail to: <a href=\"mailto:seitz@necotox.de\">seitz@necotox.de<\/a> or call +49 6346 9661491<br \/>\npicture by <a href=\"https:\/\/pixabay.com\/de\/users\/republica-24347\/?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=606612\">Republica<\/a> on <a href=\"https:\/\/pixabay.com\/de\/?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=606612\">Pixabay<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Zuvor informierten wir \u00fcber die NANOMET Workshop zum Thema\u00a0OECD-Leitfaden (GD) 317 \u00fcber die Pr\u00fcfung der aquatischen und Sedimenttoxizit\u00e4t von Nanomaterialien. Ende letzter Woche fand ein weiteres NANOMET-Online-Seminar statt. Dort wurden der Umfang, der Inhalt und die praktische Anwendung des Pr\u00fcfrichtlinie (TG) 318 wurde diskutiert. Sie konzentrierte sich insbesondere auf die Bestimmung der Aufl\u00f6sungsgeschwindigkeit, aber auch [&hellip;]<\/p>","protected":false},"author":1,"featured_media":1849,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[60],"tags":[86,84,87,43,81,88],"class_list":["post-1848","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nanoregulation-en","tag-environmental-conditions","tag-fate","tag-gd-318","tag-nanomaterial","tag-oecd-318","tag-tg-318"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Verkn\u00fcpfung Der OECD TG 318 mit Der GD 318 - nEcoTox<\/title>\n<meta name=\"description\" content=\"Linking the OECD guidance document 318 with the testing guideline 318 and more\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/necotox.de\/en\/verknupfung-der-oecd-tg-318-mit-der-gd-318\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Verkn\u00fcpfung Der OECD TG 318 mit Der GD 318 - 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